Metazoan regeneration is one of the least understood fundamental problems of biology. The
lack of progress in understanding this phenomenon at the molecular level has been due to …

Freshwater planarians were a classic model for studying the problems of development and
regeneration. However, as attention shifted towards animals with more rigid developmental …

The singular regenerative abilities of planarians require a population of stem cells known as
neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are …

Freshwater planarian flatworms are capable of regenerating complete organisms from tiny
fragments of their bodies; the basis for this regenerative prowess is an experimentally …

Conserved axon guidance mechanisms are essential for proper wiring of the nervous
system during embryogenesis; however, the functions of these cues in adults and during …

Platyhelminthes are excellent models for the study of stem cell biology,regeneration and the
regulation of scale and proportion. In addition,parasitic forms infect millions of people …

Bioactive peptides (ie, neuropeptides or peptide hormones) represent the largest class of
cell-cell signaling molecules in metazoans and are potent regulators of neural and …

Background The freshwater planarian Schmidtea mediterranea has emerged as a powerful
model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ …

The regenerative abilities of freshwater planarians are based on neoblasts, stem cells
maintained throughout the animal's life. We show that a member of the Bruno-like family of RNA …

Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess gene …