[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models

…, W Wei, W Hide, C Preuss, A Ergun, PJ Ebert… - Cell reports, 2020 - cell.com
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological …

…, W Wei, W Hide, C Preuss, A Ergun, PJ Ebert… - BioRxiv, 2019 - biorxiv.org
Alzheimer’s disease (AD) is a complex and heterogenous brain disease that affects multiple
inter-related biological processes. This complexity contributes, in part, to existing difficulties …

[PDF][PDF] THIIC, a novel mGlu2 potentiator with potential anxiolytic/antidepressant properties: In vivo profiling suggests a link between behavioral and CNS …

…, D Mayhugh, A Khilevich, D Zhang, PJ Ebert… - … of Pharmacology and …, 2010 - academia.edu
The normalization of excessive glutamatergic neurotransmission through the activation of
mGlu2 receptors may have therapeutic potential in a variety of psychiatric disorders including …

[PDF][PDF] TBL1XR1 mutations drive extranodal lymphoma by inducing a pro-tumorigenic memory fate

…, Y Kim, CR Chin, WT Yewdell, B Raught, JM Phillip… - Cell, 2020 - cell.com
The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …

[PDF][PDF] Mutant EZH2 induces a pre-malignant lymphoma niche by reprogramming the immune response

W Béguelin, M Teater, C Meydan, KB Hoehn, JM Phillip… - Cancer cell, 2020 - cell.com
Follicular lymphomas (FLs) are slow-growing, indolent tumors containing extensive follicular
dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, …

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

…, RG Waller, M Artomov, A Viale, J Patel, J Phillip… - Cancer research, 2018 - AACR
Given the frequent and largely incurable occurrence of multiple myeloma, identification of
germline genetic mutations that predispose cells to multiple myeloma may provide insight into …

From biomarkers to medical tests: the changing landscape of test evaluation

…, PJ Monaghan, WDJ Verhagen-Kamerbeek, C Ebert… - Clinica chimica acta, 2014 - Elsevier
Regulators and healthcare payers are increasingly demanding evidence that biomarkers
deliver patient benefits to justify their use in clinical practice. Laboratory professionals need to …

Deep learning identification of stiffness markers in breast cancer

…, JH Kim, PH Wu, M Habibi, M White, JM Phillip… - Biomaterials, 2022 - Elsevier
While essential to our understanding of solid tumor progression, the study of cell and tissue
mechanics has yet to find traction in the clinic. Determining tissue stiffness, a mechanical …

Elevated temperature creep-rupture behavior of the single crystal nickel-base superalloy NASAIR 100

MV Nathal, LJ Ebert - Metallurgical Transactions A, 1985 - Springer
… MacKay and Ebert have produced significant increases in creep life by refining the 7' particle
size and thus the lamellar thickness. 14 Attempts to refine the initial 7`' size in NASAIR 100 …

The influence of cobalt, tantalum, and tungsten on the microstructure of single crystal nickel-base superalloys

MV Nathal, LJ Ebert - Metallurgical Transactions A, 1985 - Springer
The influence of composition on the microstructure of single crystal nickel-base superalloys
was investigated. Co was replaced by Ni, and Ta was replaced by either Ni or W, according …