[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological …
Alzheimer’s disease (AD) is a complex and heterogenous brain disease that affects multiple
inter-related biological processes. This complexity contributes, in part, to existing difficulties …
inter-related biological processes. This complexity contributes, in part, to existing difficulties …
[PDF][PDF] THIIC, a novel mGlu2 potentiator with potential anxiolytic/antidepressant properties: In vivo profiling suggests a link between behavioral and CNS …
…, D Mayhugh, A Khilevich, D Zhang, PJ Ebert… - … of Pharmacology and …, 2010 - academia.edu
The normalization of excessive glutamatergic neurotransmission through the activation of
mGlu2 receptors may have therapeutic potential in a variety of psychiatric disorders including …
mGlu2 receptors may have therapeutic potential in a variety of psychiatric disorders including …
[PDF][PDF] TBL1XR1 mutations drive extranodal lymphoma by inducing a pro-tumorigenic memory fate
The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …
[PDF][PDF] Mutant EZH2 induces a pre-malignant lymphoma niche by reprogramming the immune response
Follicular lymphomas (FLs) are slow-growing, indolent tumors containing extensive follicular
dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, …
dendritic cell (FDC) networks and recurrent EZH2 gain-of-function mutations. Paradoxically, …
Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma
Given the frequent and largely incurable occurrence of multiple myeloma, identification of
germline genetic mutations that predispose cells to multiple myeloma may provide insight into …
germline genetic mutations that predispose cells to multiple myeloma may provide insight into …
From biomarkers to medical tests: the changing landscape of test evaluation
…, PJ Monaghan, WDJ Verhagen-Kamerbeek, C Ebert… - Clinica chimica acta, 2014 - Elsevier
Regulators and healthcare payers are increasingly demanding evidence that biomarkers
deliver patient benefits to justify their use in clinical practice. Laboratory professionals need to …
deliver patient benefits to justify their use in clinical practice. Laboratory professionals need to …
Deep learning identification of stiffness markers in breast cancer
While essential to our understanding of solid tumor progression, the study of cell and tissue
mechanics has yet to find traction in the clinic. Determining tissue stiffness, a mechanical …
mechanics has yet to find traction in the clinic. Determining tissue stiffness, a mechanical …
Elevated temperature creep-rupture behavior of the single crystal nickel-base superalloy NASAIR 100
MV Nathal, LJ Ebert - Metallurgical Transactions A, 1985 - Springer
… MacKay and Ebert have produced significant increases in creep life by refining the 7' particle
size and thus the lamellar thickness. 14 Attempts to refine the initial 7`' size in NASAIR 100 …
size and thus the lamellar thickness. 14 Attempts to refine the initial 7`' size in NASAIR 100 …
The influence of cobalt, tantalum, and tungsten on the microstructure of single crystal nickel-base superalloys
MV Nathal, LJ Ebert - Metallurgical Transactions A, 1985 - Springer
The influence of composition on the microstructure of single crystal nickel-base superalloys
was investigated. Co was replaced by Ni, and Ta was replaced by either Ni or W, according …
was investigated. Co was replaced by Ni, and Ta was replaced by either Ni or W, according …