A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of
signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified …

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …

Introduction: The bromodomain (BRD) and extra-C terminal domain (BET) protein family
consists of four members (BRD2, BRD3, BRD4 and BRDT). These “epigenetic readers” bind to …

Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize
antigens including bacterial peptidoglycans and initiate immune responses by triggering the …

Osteosarcoma (OS) survival rates have plateaued in part due to a lack of new therapeutic
options. Here we demonstrate that bromodomain inhibitors (BETi), JQ1, I-BET151, I-BET762, …

Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy,
but attempts to target essential protein biogenesis factors have been hampered by excessive …

… Sharp - Research School of Chemistry, Institute of Advanced Studies, The Australian
National University, Canberra ACT 0200, Australia, and Global Research Agricultural …

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated
approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy …

Inhibiting eukaryotic protein translation with small molecules is emerging as a powerful
therapeutic strategy. The advantage of targeting cellular translational machinery is that it is …