Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep
Genome-wide association studies (GWAS) in humans have identified loci robustly associated
with several heritable diseases or traits, yet little is known about the functional roles of the …
with several heritable diseases or traits, yet little is known about the functional roles of the …
Cigarette smoking, ambulatory cardiovascular monitoring, and mood in Vietnam veterans with and without chronic posttraumatic stress disorder
This study investigated the association among cigarette smoking, posttraumatic stress
disorder (PTSD), and ambulatory cardiovascular and mood monitoring in 117 male Vietnam …
disorder (PTSD), and ambulatory cardiovascular and mood monitoring in 117 male Vietnam …
Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
Although genome wide association studies (GWAS) have identified loci for sleep-related
traits, they do not directly uncover the underlying causal variants and corresponding effector …
traits, they do not directly uncover the underlying causal variants and corresponding effector …
Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleep
Sleep is nearly ubiquitous throughout the animal kingdom, with deficiencies in sleep having
been linked to a wide range of human disorders and diseases. While genome wide …
been linked to a wide range of human disorders and diseases. While genome wide …
Zebrafish screen of high-confidence targets at insomnia GWAS loci implicates MEIS1, SKIV2L, and ARFGAP2 as conserved regulators of sleep-wake behaviors
…, OJ Veatch, DR Mazzotti, A Krishnan, PR Gehrman… - bioRxiv, 2022 - biorxiv.org
Study objectives Insomnia is a pervasive sleep disorder with heritability estimates ranging
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
Who is predisposed to insomnia: a review of familial aggregation, stress-reactivity, personality and coping style
Insomnia is a common health complaint world-wide. Insomnia is a risk factor in the
development of other psychological and physiological disorders. Therefore understanding the …
development of other psychological and physiological disorders. Therefore understanding the …
The timing of activity rhythms in patients with dementia is related to survival
Background. Older adults with dementia often have disruptions in circadian rhythms,
including disruptions of the rest–activity rhythm. These disruptions are a product of internal …
including disruptions of the rest–activity rhythm. These disruptions are a product of internal …
Durability of treatment response to zolpidem with three different maintenance regimens: a preliminary study
…, P Gehrman, K Morales, M Thase, R Bootzin, R Ader - Sleep medicine, 2015 - Elsevier
Background and aim At present, there is no consensus regarding how to medically manage
chronic insomnia in the long term. The unstated standard of practice is for patients to use …
chronic insomnia in the long term. The unstated standard of practice is for patients to use …
Neurobiologic mechanisms in chronic insomnia
Insomnia has long been conceptualized in psychologic and physiologic terms 1; hence, the
primary diagnostic classification of ‘‘psychophysiologic’’insomnia. This diagnostic category 2 …
primary diagnostic classification of ‘‘psychophysiologic’’insomnia. This diagnostic category 2 …
[HTML][HTML] Associations between comorbid anxiety and sleep disturbance in people with bipolar disorder: Findings from actigraphy and subjective sleep measures
DJ Oakes, HA Pearce, C Roberts, PG Gehrman… - Journal of Affective …, 2022 - Elsevier
Background Studies show that comorbid anxiety disorders are common in people with
bipolar disorder. However, little is known about whether this anxiety is associated with sleep …
bipolar disorder. However, little is known about whether this anxiety is associated with sleep …