Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their
role in cancer progression is not fully elucidated. We examined the influence of PSCs on …

The field of pancreatic stellate cell (PSC) biology is very young, as the essential invitro tools
to study these cells (ie, methods to isolate and culture PSC) were only developed as recently …

Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and
their interaction with cancer cells facilitates cancer progression. This study investigated the …

Background & Aims: Activated pancreatic stellate cells have recently been implicated in
pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic …

Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined
the effects of triptolide (a diterpenoid triepoxide) on pancreatic cancer growth and local-…

The leaves of Carica papaya are generally considered waste but their extracts have been
linked with various health benefits. This study aimed to optimize extraction conditions and …

Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious
for its poor prognosis. Recent studies, via newly developed orthotopic models, provide …

Many animal models are available to investigate the pathogenesis of pancreatitis, an
inflammatory disorder of the pancreas. However, the secretagogue hyperstimulation model of …

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic
cancer tissues and can both promote and restrain disease progression. Here, we interrogate …

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic
extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over …