Dendritic cells (DCs) are antigen-presenting cells controlling T cell activation. In humans, the
diversity, ontogeny, and functional capabilities of DC subsets are not fully understood. Here…

Classical dendritic cells (cDCs) are mononuclear phagocytes of hematopoietic origin specialized
in the induction and regulation of adaptive immunity. Initially defined by their unique T …

T cells infiltrating neoplasms express surface molecules typical of chronically virus‐stimulated
T cells, often termed “exhausted” T cells. We compared the transcriptome of “exhausted” …

The transcription factor NF-κB is central to inflammatory signaling and activation of innate
and adaptive immune responses. Activation of the NF-κB pathway is tightly controlled by …

Inherent immune suppression represents a major challenge in the treatment of human cancer.
The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, …

Cutaneous squamous cell carcinoma (cSCC) development has been linked to immune
dysfunctions but the mechanisms are still unclear. Here, we report a progressive infiltration of …

NK cells and tissue-resident innate lymphoid cells (ILCs) are innate effectors found in the skin.
To investigate their temporal dynamics and specific functions throughout the development …

Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T
cell responses to model antigens, in various tumor settings. However, the impact of cross-…

Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of
adaptive immunity. Modeling cDC development is crucial to study cDCs and harness their …

Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and
modeling of the hematopoiesis in health and disease. Recapitulating the organization of …