User profiles for Pierre Larraufie
 | Pierre LarraufieAgroParisTech, institut Micalis Verified email at inrae.fr Cited by 2470 |
SCFA: mechanisms and functional importance in the gut
…, L Marinelli, HM Blottière, P Larraufie… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed
and many publications have highlighted its role as a key component of human physiology. …
and many publications have highlighted its role as a key component of human physiology. …
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa
…, M Andriamihaja, P Larraufie… - American Journal …, 2021 - journals.physiology.org
Among bacterial metabolites, hydrogen sulfide (H 2 S) has received increasing attention. The
epithelial cells of the large intestine are exposed to two sources of H 2 S. The main one is …
epithelial cells of the large intestine are exposed to two sources of H 2 S. The main one is …
[HTML][HTML] SCFAs strongly stimulate PYY production in human enteroendocrine cells
P Larraufie, C Martin-Gallausiaux, N Lapaque, J Dore… - Scientific reports, 2018 - nature.com
Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation
of food intake and insulin secretion, and are of translational interest in the field of obesity …
of food intake and insulin secretion, and are of translational interest in the field of obesity …
[PDF][PDF] Important role of the GLP-1 axis for glucose homeostasis after bariatric surgery
P Larraufie, GP Roberts, AK McGavigan, RG Kay, J Li… - Cell reports, 2019 - cell.com
Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond
expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-…
expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-…
Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling
Enteroendocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and peptide
YY that regulate food absorption, insulin secretion, and appetite. Based on the success of …
YY that regulate food absorption, insulin secretion, and appetite. Based on the success of …
[HTML][HTML] Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells
M Yang, T Darwish, P Larraufie, D Rimmington… - Scientific Reports, 2021 - nature.com
Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body
weight, the mechanisms of action are still elusive. Recent studies have identified the …
weight, the mechanisms of action are still elusive. Recent studies have identified the …
[PDF][PDF] Rab35 GTPase triggers switch-like recruitment of the lowe syndrome lipid phosphatase OCRL on newborn endosomes
…, N Gupta-Rossi, M Rocancourt, P Larraufie… - Current Biology, 2016 - cell.com
Phosphoinositide (PtdIns) homeostasis requires a tight spatial and temporal regulation
during the endocytic process [1]. Indeed, PtdIns(4,5)P 2 plays a crucial role in endocytosis by …
during the endocytic process [1]. Indeed, PtdIns(4,5)P 2 plays a crucial role in endocytosis by …
[HTML][HTML] Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal …
C Martin-Gallausiaux, P Larraufie, A Jarry… - Frontiers in …, 2018 - frontiersin.org
Commensal bacteria are crucial for the development and maintenance of a healthy immune
system therefore contributing to the global well-being of their host. A wide variety of …
system therefore contributing to the global well-being of their host. A wide variety of …
TLR ligands and butyrate increase Pyy expression through two distinct but inter‐regulated pathways
P Larraufie, J Doré, N Lapaque… - Cellular …, 2017 - Wiley Online Library
The intestinal epithelium is an active barrier separating the host from its microbiota. It senses
microbial compounds through expression of a wide range of receptors including the Toll‐…
microbial compounds through expression of a wide range of receptors including the Toll‐…
[HTML][HTML] Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice–identification of selective stimuli for insulin-like peptide-5 and glucagon-like …
Objective Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial
layer, are known to express different hormones, with at least partial co-expression of …
layer, are known to express different hormones, with at least partial co-expression of …