Epigenetic inheritance in mammals relies in part on robust propagation of DNA methylation
patterns throughout development. We show that the protein UHRF1 (ubiquitin-like, …

Chromatin methylation is necessary for stable repression of gene expression during mammalian
development. During cell division, DNMT1 maintains the DNA methylation pattern of the …

Mammalian euchromatic gene silencing results from the combined repressive effects of histone
and DNA methyltransferases. Little is known of the mechanism by which these enzymes …

Inheritance of epigenetic information encoded by cytosine DNA methylation patterns is
crucial for mammalian cell survival, in large part through the activity of the maintenance DNA …

The regulation of matrix metalloproteinase-9 (MMP-9) expression in glioma cells is one of
the key processes in tumor invasion through the brain extracellular matrix. Although some …

UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain
protein associated with cellular proliferation and epigenetic regulation. The UHRF1 binds to …

The protein lysine methyltransferase SET7 regulates DNA methyltransferase-1 (DNMT1)
activity in mammalian cells by promoting degradation of DNMT1 and thus allows epigenetic …

Cytosine residues in the vertebrate genome are enzymatically modified to 5-methylcytosine,
which participates in transcriptional repression of genes during development and disease …

DNA (cytosine-5)-methyltransferase (DNMT) 1 participates in transcriptional repression of
genes by methylation-dependent and -independent mechanisms. Here, DNMT1 is shown to …

Lysine-specific murine histone H3 methyltransferase, G9a, was expressed and purified in a
baculovirus expression system. The primary structure of the recombinant enzyme is identical …