The hippocampus is a brain area central for cognition. Mutations in the human SOX2 transcription
factor cause neurodevelopmental defects, leading to intellectual disability and seizures…

Simple Summary Despite major recent therapeutic advances, melanoma remains the deadliest
form of skin cancer due to the capacity of melanoma cells to adapt to drug treatment and …

Melanoma cell phenotype switching between differentiated melanocytic and undifferentiated
mesenchymal‐like states drives metastasis and drug resistance. CDK7 is the serine/…

The transcriptional response to genotoxic stress involves gene expression arrest, followed
by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 …

TFIIH is a 10-subunit complex involved in transcription and DNA repair. It contains several
enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-…

Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of
key genes associated with cell function. The identification of cancer-specific SE-driven genes …

The dynamic cellular transitions exhibited by skin cutaneous melanoma (SKCM) cells present
a significant challenge to current therapeutic approaches, emphasizing the critical need …

Melanoma cells switch back-and-forth between phenotypes of proliferation and invasion in
response to changing microenvironment, driving metastatic progression. We show that …

theses.fr – Pietro Berico, Addiction transcriptionnelle des cellules de mélanome et impact
de la kinaie CDK7 du facteur TFIIH … par Pietro Berico …

Founding Chair of the Department of Integrative Translational Sciences within Beckman
Research Institute of City of Hope. In addition, he will also become Deputy Director of …