User profiles for Pietro Di Lena

Pietro Di Lena

Associate Professor, Department of Computer Science and Engineering - University of …
Verified email at unibo.it
Cited by 1382

Deep architectures for protein contact map prediction

P Di Lena, K Nagata, P Baldi - Bioinformatics, 2012 - academic.oup.com
Motivation: Residue–residue contact prediction is important for protein structure prediction
and other applications. However, the accuracy of current contact predictors often barely …

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

…, K Ozturk, H Carter, G Babbi, S Bovo, P Di Lena… - Genome …, 2024 - cris.unibo.it
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the
state-of-the-art for computational prediction of genetic variant impact, particularly where …

Reconstruction of 3D structures from protein contact maps

M Vassura, L Margara, P Di Lena… - IEEE/ACM …, 2008 - ieeexplore.ieee.org
Pietro Di Lena received the Laurea degree in informatica and the Dottorato di Ricerca in
informatica (PhD degree in computer science) from the University of Bologna, Italy, in 2003 and …

[HTML][HTML] Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling

B Tang, P Di Lena, L Schaffer, SR Head, P Baldi… - PLoS …, 2011 - journals.plos.org
B-cell leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant
expression in the striatum. To date, there are no known gene targets of Bcl11b in the nervous …

Missing value estimation methods for DNA methylation data

P Di Lena, C Sala, A Prodi, C Nardini - Bioinformatics, 2019 - academic.oup.com
Motivation DNA methylation is a stable epigenetic mark with major implications in both
physiological (development, aging) and pathological conditions (cancers and numerous diseases…

Evaluation of different computational methods for DNA methylation-based biological age

P Di Lena, C Sala, C Nardini - Briefings in Bioinformatics, 2022 - academic.oup.com
In recent years there has been a widespread interest in researching biomarkers of aging that
could predict physiological vulnerability better than chronological age. Aging, in fact, is one …

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges

…, S Bovo, PL Martelli, G Babbi, PD Lena… - Human …, 2017 - Wiley Online Library
Precision medicine aims to predict a patient's disease risk and best therapeutic options by
using that individual's genetic sequencing data. The Critical Assessment of Genome …

Optimal global alignment of signals by maximization of Pearson correlation

P Di Lena, L Margara - Information Processing Letters, 2010 - Elsevier
The problem of detecting the similarity between noisy signals obtained from electronic
instrument measurements arises in several different contexts and it is approached with specific …

Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for …

…, K Ozturk, H Carter, G Babbi, S Bovo, P Di Lena… - Genome …, 2024 - iris.uniroma1.it
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the
state-of-the-art for computational prediction of genetic variant impact, particularly where …

FT-COMAR: fault tolerant three-dimensional structure reconstruction from protein contact maps

M Vassura, L Margara, P Di Lena, F Medri… - …, 2008 - academic.oup.com
Fault Tolerant Contact Map Reconstruction (FT-COMAR) is a heuristic algorithm for the
reconstruction of the protein three-dimensional structure from (possibly) incomplete (ie containing …