As radio- and chemotherapy-based cancer treatments affect both tumors and healthy tissue,
cancer immunotherapy attempts to specifically enhance the natural immune response to …

We have performed a series of in vitro tests proposed for the reliable assessment of safety
associated with nanoparticles-cell interaction. A thorough analysis of toxicity of three different …

The cationic porphyrin meso-tetra(4- N -methylpyridyl)porphine (TMPyP) has a high yield of
singlet oxygen generation upon light activation and a strong affinity for DNA. These …

Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in
the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for …

Pancreatic cancer is a devastating disease with very poor prognosis. Currently, surgery
followed by adjuvant chemotherapy represents the only curative option which, unfortunately, is …

Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased
expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate …

The combined application of two photosensitisers (PSs), zinc(ii) phthalocyanine (ZnPc) and
the cationic porphyrinmeso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells …

p53 is a tumor suppressor, which belongs to the p53 family of proteins. The family consists
of p53, p63 and p73 proteins, which share similar structure and function. Activation of wild-…

Cholangiocarcinoma is an uncommon and highly aggressive biliary tract malignancy with
few manifestations until late disease stages. Diagnosis is currently achieved through a …

Pancreatic cancer is one of the deadliest cancers partly due to late diagnosis, poor drug
delivery to the target site, and acquired resistance to therapy. Therefore, more effective …