Most patients with advanced malignancies are treated with severely toxic, first-line chemotherapies.
Personalized treatment strategies have led to improved patient outcomes and could …

Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy
is poorly understood. In this study, we investigate the initial signaling response to …

The principle of drug sensitivity testing is to expose cancer cells to a library of different drugs
and measure its effects on cell viability. Recent technological advances, continuous …

Motivation There is a rapidly growing interest in high-throughput drug combination screening
to identify synergizing drug interactions for treatment of various maladies, such as cancer …

Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia
and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond …

Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where
mechanisms of inter-leukemic communication and cell-to-cell interactions are proposed to be …

Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment
alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor …

Robustness and completion of DNA replication rely on redundant DNA replication origins.
Reduced efficiency of origin licensing is proposed to contribute to chromosome instability in …

Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies,
but eventually relapse and develop resistance. Novel treatment strategies are therefore …

Current treatment selection for acute myeloid leukemia (AML) patients depends on risk
stratification based on cytogenetic and genomic markers. However, the forecasting accuracy of …