MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases …

Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range
of pomegranate’s health benefits. While a lot of experimental studies have been devoted …

MicroRNAs (miRs) are important post-transcriptional regulators of gene expression
implicated in neuronal development, differentiation, aging and neurodegenerative diseases, …

Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

A molecular hallmark in Parkinson's disease (PD) pathogenesis are α-synuclein aggregates.
Cerebral dopamine neurotrophic factor (CDNF) is an atypical growth factor that is mostly …

Background Parkinson's disease (PD) is associated with proteostasis disturbances and
accumulation of misfolded α‐synuclein (α‐syn), a cytosolic protein present in high …

Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by
motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as …

Currently used antipsychotics are characterized by multireceptor mode of action. While
antagonism of dopamine D 2 receptors is responsible for the alleviation of “positive” symptoms of …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)
localized protein that regulates ER homeostasis and unfolded protein response (UPR). …

The goal of this protocol is to establish a robust and reproducible model of α-synuclein
accumulation in primary dopamine neurons. Combined with immunostaining and unbiased …