Dicer-dependent noncoding RNAs, including microRNAs (miRNAs), play an important role
in a modulation of translation of mRNA transcripts necessary for differentiation in many cell …

Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity
plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme …

An increasing body of data has shown that matrix metalloproteinase-9 (MMP-9), an extracellularly
acting, Zn 2+ -dependent endopeptidase, is important not only for pathologies of the …

Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA
receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 …

Matrix metalloproteinase-9 has recently emerged as an important molecule in control of
extracellular proteolysis in the synaptic plasticity. However, no synaptic targets for its enzymatic …

Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Rewiring of synaptic circuitry pertinent to memory formation has been associated with
morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, …

Learning how to avoid danger and pursue reward depends on negative emotions motivating
aversive learning and positive emotions motivating appetitive learning. The amygdala is a …

Glutamate uptake by astroglial transporters confines excitatory transmission to the synaptic
cleft. The efficiency of this mechanism depends on the transporter dynamics in the astrocyte …

Electric fields of synaptic currents can influence diffusion of charged neurotransmitters, such
as glutamate, in the synaptic cleft. However, this phenomenon has hitherto been detected …