The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity
remains unknown. This study shows that hypoxia-induced resistance of lung tumor to …

Most neurological diseases are associated with chronic inflammation initiated by the activation
of microglia, which produce cytotoxic and inflammatory factors. Signal transducers and …

Gliomas attract brain‐resident (microglia) and peripheral macrophages and reprogram
these cells into immunosuppressive, pro‐invasive cells. M‐ CSF (macrophage colony‐stimulating …

Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic
activity, especially when paired with cancer immunotherapies. Here we explore the …

Glioblastoma (GBM) contains rare glioma stem-like cells (GSCs) with capacities of self-renewal,
multi-lineage differentiation, and resistance to conventional therapy. Drug-induced …

Glioblastoma (GBM) is an aggressive malignancy associated with profound host
immunosuppression. Microglia and macrophages infiltrating GBM acquire the pro-tumorigenic, M2 …

Rett syndrome (RTT) is a genetic disorder resulting from a loss-of-function mutation in one
copy of the X-linked gene methyl-CpG–binding protein 2 (MECP2). Typical RTT patients are …

Background Malignant tumours release factors, which attract myeloid cells and induce their
polarisation to pro-invasive, immunosuppressive phenotypes. Brain-resident microglia and …

Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been
disappointing due to limited tumor-specific antibody-dependent cellular cytotoxicity. Here …

Many lncRNAs have been discovered using transcriptomic data; however, it is unclear what
fraction of lncRNAs is functional and what structural properties affect their phenotype. MUNC …