Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for
schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene …

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional
mutation causally related to the disorder has yet been identified. Here we investigate the …

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2
are associated with sporadic forms of cerebral small vessel disease. Methods: We …

Schizophrenia and related disorders have a major genetic component. Several large-scale
studies have uncovered a number of possible candidate genes, but these have yet to be …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …

Psychiatric disorders are highly heritable, and in many individuals likely arise from the
combined effects of genes and the environment. A substantial body of evidence points toward …

Stress is associated with poorer physical and mental health. To improve our understanding
of this link, we performed genome-wide association studies (GWAS) of depressive symptoms …

Depression has well-established influences from genetic and environmental risk factors.
This has led to the diathesis-stress theory, which assumes a multiplicative gene-by-environment …

Few replicable genetic associations for Major Depressive Disorder (MDD) have been
identified. Recent studies of MDD have identified common risk variants by using a broader …