User profiles for Pirta Hotulainen

Pirta Hotulainen

Verified email at helsinki.fi
Cited by 5065

Actin in dendritic spines: connecting dynamics to function

P Hotulainen, CC Hoogenraad - Journal of Cell Biology, 2010 - rupress.org
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing and …

Mechanisms of actin stress fibre assembly

…, P Lappalainen, P Hotulainen - Journal of …, 2008 - Wiley Online Library
Stress fibres are contractile acto‐myosin structures found from many types of non‐muscle
cells, where they are involved in adhesion, motility and morphogenesis. Stress fibres typically …

[HTML][HTML] A look into the future of the COVID-19 pandemic in Europe: an expert consultation

…, E Glaab, E Grill, C Hanson, P Hotulainen… - The Lancet Regional …, 2021 - thelancet.com
How will the coronavirus disease 2019 (COVID-19) pandemic develop in the coming months
and years? Based on an expert survey, we examine key aspects that are likely to influence …

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

P Hotulainen, P Lappalainen - The Journal of cell biology, 2006 - rupress.org
Stress fibers play a central role in adhesion, motility, and morphogenesis of eukaryotic cells,
but the mechanism of how these and other contractile actomyosin structures are generated …

Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells

P Hotulainen, E Paunola, MK Vartiainen… - Molecular biology of …, 2005 - Am Soc Cell Biol
Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all
eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing actin …

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

P Hotulainen, O Llano, S Smirnov… - Journal of Cell …, 2009 - rupress.org
Dendritic spines are small protrusions along dendrites where the postsynaptic components
of most excitatory synapses reside in the mature brain. Morphological changes in these actin-…

[PDF][PDF] A molecular pathway for myosin II recruitment to stress fibers

S Tojkander, G Gateva, G Schevzov, P Hotulainen… - Current Biology, 2011 - cell.com
Background Cell migration and morphogenesis are driven by both protrusive and contractile
actin filament structures. The assembly mechanisms of lamellipodial and filopodial actin …

Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells

E Bertling, P Hotulainen, PK Mattila… - Molecular biology of …, 2004 - Am Soc Cell Biol
Cyclase-associated proteins (CAPs) are highly conserved actin monomer binding proteins
present in all eukaryotes. However, the mechanism by which CAPs contribute to actin …

[HTML][HTML] An action plan for pan-European defence against new SARS-CoV-2 variants

…, I Eckerle, G Giordano, C Hanson, Z Hel, P Hotulainen… - The Lancet, 2021 - thelancet.com
COVID-19 cases are very high across Europe. Current measures are not reducing virus
spread sufficiently, and new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Contractility-dependent actin dynamics in cardiomyocyte sarcomeres

A Skwarek-Maruszewska, P Hotulainen… - Journal of cell …, 2009 - journals.biologists.com
In contrast to the highly dynamic actin cytoskeleton in non-muscle cells, actin filaments in
muscle sarcomeres are thought to be relatively stable and undergo dynamics only at their ends…