Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
The multitarget-directed strategy offers an effective and promising paradigm to treat the
complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-…
complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-…
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging
population worldwide. The enormous challenge which AD possesses to global healthcare …
population worldwide. The enormous challenge which AD possesses to global healthcare …
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1, 3, 4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease
The diverse nature of Alzheimer's disease (AD) has prompted researchers to develop multi-functional
agents. Herein, we have designed and synthesized molecular hybrids of 2-…
agents. Herein, we have designed and synthesized molecular hybrids of 2-…
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and …
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual
screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having …
screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having …
Conceptual captions: A cleaned, hypernymed, image alt-text dataset for automatic image captioning
We present a new dataset of image caption annotations, Conceptual Captions, which contains
an order of magnitude more images than the MS-COCO dataset (Lin et al., 2014) and …
an order of magnitude more images than the MS-COCO dataset (Lin et al., 2014) and …
[HTML][HTML] Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: a comparative assessment
The objective of work was to formulate, evaluate and compare the transdermal potential of
novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing …
novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing …
Albert: A lite bert for self-supervised learning of language representations
Increasing model size when pretraining natural language representations often results in
improved performance on downstream tasks. However, at some point further model increases …
improved performance on downstream tasks. However, at some point further model increases …
Biphenyl-3-oxo-1, 2, 4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
A series of novel piperazine tethered biphenyl-3-oxo-1,2,4-triazine derivatives were designed,
and synthesized. Amongst the synthesized analogs, compound 6g showed significant non…
and synthesized. Amongst the synthesized analogs, compound 6g showed significant non…
Conceptual 12m: Pushing web-scale image-text pre-training to recognize long-tail visual concepts
The availability of large-scale image captioning and visual question answering datasets has
contributed significantly to recent successes in vision-and-language pre-training. However, …
contributed significantly to recent successes in vision-and-language pre-training. However, …
Managing uncertainty during a global pandemic: An international business perspective
Despite the perennial need to understand and manage uncertainty in international business,
there is no comprehensive framework that incorporates different types of uncertainty, their …
there is no comprehensive framework that incorporates different types of uncertainty, their …