User profiles for Piyush Padhi

Piyush Padhi

University of Georgia
Verified email at uga.edu
Cited by 100

[HTML][HTML] Mechanistic insights into gut microbiome dysbiosis-mediated neuroimmune dysregulation and protein misfolding and clearance in the pathogenesis of …

P Padhi, C Worth, G Zenitsky, H Jin… - Frontiers in …, 2022 - frontiersin.org
The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms.
Beginning as early as in utero fetal development and continuing through birth to late-…

Clostridioides difficile infection dysregulates brain dopamine metabolism

AA Vinithakumari, P Padhi, B Hernandez… - Microbiology …, 2022 - Am Soc Microbiol
Gastrointestinal illnesses and dysbiosis are among the most common comorbidities reported
in patients with neurodevelopmental disorders. The manuscript reports that C. difficile …

[HTML][HTML] Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression

…, BN Palanisamy, E Malovic, SK Nethi, P Padhi… - Biomolecules, 2023 - mdpi.com
To date, there is no cure for Parkinson’s disease (PD). There is a pressing need for anti-neurodegenerative
therapeutics that can slow or halt PD progression by targeting underlying …

Utilization of the CRISPR-Cas9 gene editing system to dissect neuroinflammatory and neuropharmacological mechanisms in Parkinson's disease

J Luo, P Padhi, H Jin, V Anantharam, G Zenitsky… - Journal of Neuroimmune …, 2019 - Springer
Chronic and debilitating neurodegenerative diseases, such as Parkinson’s disease (PD),
impose an immense medical, emotional, and economic burden on patients and society. Due to …

[HTML][HTML] Midazolam efficacy against acute hydrogen sulfide-induced mortality and neurotoxicity

…, EM Whitley, B Mahama, P Imerman, P Padhi… - Journal of medical …, 2018 - Springer
Hydrogen sulfide (H 2 S) is a colorless, highly neurotoxic gas. It is not only an occupational
and environmental hazard but also of concern to the Department of Homeland Security for …

[HTML][HTML] Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and …

M Ay, A Charli, M Langley, A Jang, P Padhi… - Frontiers in …, 2024 - frontiersin.org
Impaired mitochondrial function and biogenesis have strongly been implicated in the
pathogenesis of Parkinson’s disease (PD). Thus, identifying the key signaling mechanisms …

Transcriptomic profile analysis of brain inferior colliculus following acute hydrogen sulfide exposure

DS Kim, P Anantharam, P Padhi, DR Thedens, G Li… - Toxicology, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is a gaseous molecule found naturally in the environment, and as
an industrial byproduct, and is known to cause acute death and induces long-term …

[HTML][HTML] Mitoapocynin Attenuates Organic Dust Exposure-Induced Neuroinflammation and Sensory-Motor Deficits in a Mouse Model

N Massey, D Shrestha, SM Bhat, P Padhi… - Frontiers in Cellular …, 2022 - frontiersin.org
Increased incidences of neuroinflammatory diseases in the mid-western USA have been
linked to exposure to agriculture contaminants. Organic dust (OD) is a major contaminant in the …

Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene

BK Padhi, JS Zigler Jr, P Padhi, S Hose, D Sinha - genesis, 2014 - Wiley Online Library
The transforming acidic coiled‐coil containing protein 2 (Tacc2) gene and its paralogs,
Tacc1 and Tacc3 encode proteins that are associated with the centrosome and involved in …

Clostridioides difficile infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism spectrum disorders …

AA Vinithakumari, P Padhi, B Hernandez, S Je-Han Lin… - bioRxiv, 2021 - biorxiv.org
Gastrointestinal illnesses are one of the most common comorbidities reported in patients with
neurodevelopmental diseases, including autism spectrum disorders (ASD). Gut dysbiosis, …