Label-free spectroscopic SARS-CoV-2 detection on versatile nanoimprinted substrates
Widespread testing and isolation of infected patients is a cornerstone of viral outbreak
management, as underscored during the ongoing COVID-19 pandemic. Here, we report a large-…
management, as underscored during the ongoing COVID-19 pandemic. Here, we report a large-…
Furin‐mediated self‐assembly of olsalazine nanoparticles for targeted Raman imaging of tumors
Olsalazine (Olsa) is a broad‐spectrum anti‐cancer agent acting as a DNA‐methylation
inhibitor. When conjugated to 2‐cyano‐6‐aminobenzothiazole and a peptide substrate specific …
inhibitor. When conjugated to 2‐cyano‐6‐aminobenzothiazole and a peptide substrate specific …
Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is one of the most common malignancies that account
for nearly one-third of all pediatric cancers. The current diagnostic assays are time-consuming…
for nearly one-third of all pediatric cancers. The current diagnostic assays are time-consuming…
A Dual‐Modal Single‐Antibody Plasmonic Spectro‐Immunoassay for Detection of Small Molecules
Small molecules play a pivotal role in regulating physiological processes and serve as
biomarkers to uncover pathological conditions and the effects of therapeutic treatments. However, …
biomarkers to uncover pathological conditions and the effects of therapeutic treatments. However, …
Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy
Quantitative phase imaging (QPI) is a powerful optical imaging modality for label-free, rapid,
and three-dimensional (3D) monitoring of cells and tissues. However, molecular imaging of …
and three-dimensional (3D) monitoring of cells and tissues. However, molecular imaging of …
Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation
White adipose tissue (WAT) and brown adipose tissue (BAT) are the primary types of fats in
humans, and they play prominent roles in energy storage and thermogenesis, respectively. …
humans, and they play prominent roles in energy storage and thermogenesis, respectively. …
Leveraging Nanomechanical Perturbations in Raman Spectro‐Immunoassays to Design a Versatile Serum Biomarker Detection Platform
While immunoassays are pivotal to medical diagnosis and bioanalytical chemistry, the
current landscape of public health has catalyzed an important shift in the requirements of …
current landscape of public health has catalyzed an important shift in the requirements of …
Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential
Identification of the metastatic potential represents one of the most important tasks for molecular
imaging of cancer. While molecular imaging of metastases has witnessed substantial …
imaging of cancer. While molecular imaging of metastases has witnessed substantial …
Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy
This study provides first-in-class evidence that optical spectroscopy allows sensitive
detection of early changes in the biomolecular composition of tumors that predict response to …
detection of early changes in the biomolecular composition of tumors that predict response to …
Stable High‐Conductivity Ethylenedioxythiophene Polymers via Borane‐Adduct Doping
Efficient doping of polymer semiconductors is required for high conductivity and efficient
thermoelectric performance. Lewis acids, eg, B(C 6 F 5 ) 3 , have been widely employed as …
thermoelectric performance. Lewis acids, eg, B(C 6 F 5 ) 3 , have been widely employed as …