Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated
in the regulation of many cellular processes, including the cell cycle, circadian rhythms, …

The von Hippel–Lindau (VHL) protein serves to recruit the hypoxia-inducible factor alpha (HIF1α)
protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and …

Zebrafish xenotransplantation models are increasingly applied for phenotypic drug screening
to identify small compounds for precision oncology. Larval zebrafish xenografts offer the …

The eight members of the FAM83 (FAMily with sequence similarity 83) family of poorly
characterised proteins are only present in vertebrates and are defined by the presence of the …

Our previous studies of PAWS1 (protein associated with SMAD1; also known as FAM83G)
have suggested that this molecule has roles beyond BMP signalling. To investigate these …

AIM: Recently, the concept that high density lipoprotein (HDL) quality is an important parameter
for atheroprotection is gaining ground, though little data exists so far to support it. In an …

The BMP and Wnt signalling pathways determine axis specification during embryonic
development. Our previous work has shown that PAWS 1 (also known as FAM 83G) interacts with …

Transcriptional reporter systems allow researchers to investigate the function and regulation
of transcription factors. Conventional systems employ artificial cDNA overexpression vectors …

Early childhood tumours are thought to arise from transformed embryonic cells, which often
carry large copy number variants (CNVs). However, it remains unclear how CNVs contribute …

Early childhood malignancies are driven by sparse genetic aberrations in oncogenes that
often co-occur with large copy number variants (CNVs). The combination of these mutations is …