Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is
synthesized from methionine as an important intermediate in the one-carbon pathway. High …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

The epigenome is associated with biological factors, such as disease status, and environmental
factors, such as smoking, alcohol consumption and body mass index. Although there is …

We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to
describe the DNA methylation signature of chronic low-grade inflammation as measured by C-…

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy
exposure and in adults from personal smoking. Whether a unique methylation signature …

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity,
our understanding of its functional relevance remains limited. Here we show the effect of …

Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …

Rationale We aimed to identify differentially methylated regions (DMRs) in cord blood DNA
associated with childhood lung function, asthma and chronic obstructive pulmonary disease (…

Background A large number of analysis strategies are available for DNA methylation (DNAm)
array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare …

Background DNA methylation at the GFI1-locus has been repeatedly associated with exposure
to smoking from the foetal period onwards. We explored whether DNA methylation may …