Rationale: Macrophages change their phenotype and biological functions depending on the
microenvironment. In atherosclerosis, oxidative tissue damage accompanies chronic …

Mitochondria form a complex, interconnected reticulum that is maintained through coordination
among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in …

… Author links open overlay panel Alexandra Kadl a b , Poonam R. Sharma a b , Wenshu
Chen a b , Rachana Agrawal a b , Akshaya K. Meher a b , Swetha Rudraiah a b , Nathaniel …

Elevated levels of circulating proinflammatory cytokines are associated with obesity and
increased risk of type 2 diabetes, but the mechanism is unknown. We tested whether …

The soy phytoestrogen, genistein, induces thymic atrophy when administered to ovariectomized
mice by injection or in the diet. Injected genistein also causes decreased humoral …

CD4+ Foxp3+ regulatory T cells (Tregs) protect the kidney during AKI. We previously found
that IL-2, which is critical for Treg homeostasis, upregulates the IL-33 receptor (ST2) on CD4+ …

Acute and chronic tissue injury results in the generation of a myriad of environmental cues
that macrophages respond to by changing their phenotype and function. This phenotypic …

Microneedle patch devices have been widely utilized for transdermal drug delivery in pain
management, but is challenged by accurate control of drug release and subsequent diffusion …

Obesity-linked (type 2) diabetic nephropathy (T2DN) has become the largest contributor to
morbidity and mortality in the modern world. Recent evidences suggest that inflammation may …

Activation of the transcription factor NF-E2-related factor 2 (Nrf2) by oxidative stress induces
the expression of a variety of antioxidant and anti-inflammatory genes. Yet, genetic ablation …