Large-scale cancer sequencing data enable discovery of rare germline cancer susceptibility
variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas …

Local concentrations of mutations are well known in human cancers. However, their three-dimensional
spatial relationships in the encoded protein have yet to be systematically explored…

Background Quantifying morphologic changes is critical to our understanding of the
pathophysiology of the lung. Mean linear intercept (MLI) measures are important in the assessment …

A database of curated genomic variants with clinically supported drug therapies and other
oncological annotations is described. The accompanying web portal provides a search …

Basal cell cancers (BCCs) are characterized by upregulation of Hedgehog pathway through
loss of PTCH1 or activation of SMO, and SMO inhibitors, such as vismodegib, are effective …

Introduction: We present 2 cases in which typically irreversible lichen planopilaris (LPP) and
frontal fibrosing alopecia (FFA) showed signs of reversal. Case Presentation: A 27-year-old …

High throughput sequencing has facilitated a precipitous drop in the cost of genomic
sequencing, prompting predictions of a revolution in medicine via genetic personalization of …

To the Editor: Chronic medication-induced immunosuppression is a known risk factor for
keratinocyte cancer (KC). 1-3 To determine which immunosuppressants are most significantly …

To the editor: Basal cell carcinoma (BCC) is the most common malignancy in the United
States. 1 More than 41% of patients with 2 or more BCCs develop a subsequent BCC. 2, 3 …

Background: Awake craniotomy is currently the gold standard for aggressive tumor resections
in eloquent cortex. However, a significant subset of patients is unable to tolerate this …