User profiles for Prajish Iyer
 | Prajish IyerCITY OF HOPE Verified email at coh.org Cited by 335 |
[HTML][HTML] SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation
…, L Yang, M Jin, M Fernandez, P Iyer… - The Journal of …, 2023 - Am Soc Clin Investig
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic
malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm …
malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm …
[HTML][HTML] Non-typhoidal Salmonella DNA traces in gallbladder cancer
Background We earlier proposed a genetic model for gallbladder carcinogenesis and its
dissemination cascade. However, the association of gallbladder cancer and ‘inflammatory …
dissemination cascade. However, the association of gallbladder cancer and ‘inflammatory …
ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer
The uncommonness of gallbladder cancer in the developed world has contributed to the
generally poor understanding of the disease. Our integrated analysis of whole exome …
generally poor understanding of the disease. Our integrated analysis of whole exome …
[HTML][HTML] Emerging therapies in CLL in the era of precision medicine
Simple Summary Despite being a slow-proliferating disease, chronic lymphocytic leukemia (CLL)
is an incurable and frequently reoccurring adult leukemia. Although large-scale …
is an incurable and frequently reoccurring adult leukemia. Although large-scale …
Inhibition of SETMAR–H3K36me2–NHEJ repair axis in residual disease cells prevents glioblastoma recurrence
Background Residual disease of glioblastoma (GBM) causes recurrence. However, targeting
residual cells has failed, due to their inaccessibility and our lack of understanding of their …
residual cells has failed, due to their inaccessibility and our lack of understanding of their …
[HTML][HTML] Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations
Introduction: Unlike lung adenocarcinoma patients, there is no FDA-approved targeted-therapy
likely to benefit lung squamous cell carcinoma patients. Materials and Methods: We …
likely to benefit lung squamous cell carcinoma patients. Materials and Methods: We …
[HTML][HTML] TMC-SNPdb: an Indian germline variant database derived from whole exome sequences
Cancer is predominantly a somatic disease. A mutant allele present in a cancer cell genome
is considered somatic when it’s absent in the paired normal genome along with public SNP …
is considered somatic when it’s absent in the paired normal genome along with public SNP …
[HTML][HTML] Unveiling ATF6 and PPM1H signaling in hepatocellular carcinoma progression: From ER stress to tumor suppression
P Iyer, S Oberai, B Jiang, D Marimekala - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Liver cancer is one of the sixth most common cancers, a global threat to world cancer health,
with 8, 41,000 new cases and 782,000 deaths yearly worldwide per GLOBOCAN, 2018. 1 …
with 8, 41,000 new cases and 782,000 deaths yearly worldwide per GLOBOCAN, 2018. 1 …
[HTML][HTML] Integrated genomics approach to identify biologically relevant alterations in fewer samples
Background Several statistical tools have been developed to identify genes mutated at rates
significantly higher than background, indicative of positive selection, involving large sample …
significantly higher than background, indicative of positive selection, involving large sample …
MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS
Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to
aggressive lymphoma. MGA (Max gene associated), a functional MYC suppressor, is mutated at 3…
aggressive lymphoma. MGA (Max gene associated), a functional MYC suppressor, is mutated at 3…