Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The
cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of …

Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory
sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a …

Neutrophils can function and survive in injured and infected tissues, where oxygen and
metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U- 13 C …

Neutrophils are predominantly glycolytic cells that derive little ATP from oxidative
phosphorylation; however, they possess an extensive mitochondrial network and maintain a …

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal
complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and …

Fully activated innate immune cells are required for effective responses to infection, but their
prompt deactivation and removal are essential for limiting tissue damage. Here, we have …

Hypoxia and bacterial infection frequently coexist, in both acute and chronic clinical settings,
and typically result in adverse clinical outcomes. To ameliorate this morbidity, we …

Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with
a high mortality that is currently in focus given that it is associated with mortality caused by …

Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration
and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. …

Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires
a better understanding of the processes that dictate neutrophil function in the tissues. …