Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier
family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes. Here …

Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health
problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer-…

Many intracellular pathogens infect macrophages and these pathogens require iron for
growth. Here we demonstrate in vitro that the intracellular growth of Chlamydia psittaci, …

Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the
mitochondrial inner membrane, functions as an essential iron importer for the synthesis of …

Heme biosynthesis consists of a series of eight enzymatic reactions that originate in
mitochondria and continue in the cytosol before returning to mitochondria. Although these core …

RNA viruses exhibit substantial structural, ecological and genomic diversity. However, genome
size in RNA viruses is likely limited by a high mutation rate, resulting in the evolution of …

Dengue virus (DENV) infections continue to spread aggressively around the world. Here we
demonstrate that celgosivir (6-O-butanoyl castanospermine), strongly inhibits all four DENV …

The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA
replication. It contains an N-terminal serine protease region (residues 1–168) joined to an …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus …

Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread
a desired allele through a population, have the potential to transform the way societies …