[HTML][HTML] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
…, L Chong, N Thomas, P Pararajalingam… - Nature …, 2018 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells.
Prognosis is strongly associated with molecular subgroup, although the driver mutations …
Prognosis is strongly associated with molecular subgroup, although the driver mutations …
Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing
Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is
incurable with standard therapies. The genetic drivers of this cancer have not been firmly …
incurable with standard therapies. The genetic drivers of this cancer have not been firmly …
Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns
Follicular lymphoma (FL) accounts for ∼20% of all new lymphoma cases. Increases in
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
Molecular determinants of outcomes in relapsed or refractory mantle cell lymphoma treated with ibrutinib or temsirolimus in the MCL3001 (RAY) trial
CL Freeman, P Pararajalingam, L Jin… - Leukemia, 2022 - nature.com
Mantle cell lymphoma (MCL) is a rare, incurable lymphoma subtype characterized by
heterogeneous outcomes. To better understand the clinical behavior and response to treatment, …
heterogeneous outcomes. To better understand the clinical behavior and response to treatment, …
Enhancing knowledge discovery from cancer genomics data with Galaxy
The field of cancer genomics has demonstrated the power of massively parallel sequencing
techniques to inform on the genes and specific alterations that drive tumor onset and …
techniques to inform on the genes and specific alterations that drive tumor onset and …
Large-Scale Genomic Analysis of Mutational Hotspots in Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma
Introduction: The diverse pathways that are deregulated during the malignant transformation
of B-cells have been identified for many of the common mature B cell neoplasms, but a …
of B-cells have been identified for many of the common mature B cell neoplasms, but a …
[HTML][HTML] An Open-Source Toolkit That Powers the Genome-Wide Analysis of Mature B-Cell Lymphomas (GAMBL) Project
…, J Wong, L Sethi, CK Rushton, P Pararajalingam… - Blood, 2021 - Elsevier
Introduction: Genome- and transcriptome-wide analyses continue to enhance our
understanding of the molecular pathogenesis of cancer. In lymphomas, this has enabled the …
understanding of the molecular pathogenesis of cancer. In lymphomas, this has enabled the …
Exploring Splicing Factor Aberrations As a Therapeutic Target in Mature B-Cell Malignancies
Objectives Cancers originating from mature B cells at various stages of terminal differentiation
represent a diverse set of cancers. There are numerous pathological subtypes, each …
represent a diverse set of cancers. There are numerous pathological subtypes, each …
Genetic and molecular characterization of mantle cell lymphoma
P Pararajalingam - 2023 - summit.sfu.ca
Despite advances in treatment and disease management, Mantle Cell Lymphoma (MCL)
remains an incurable disease where patients typically succumb to the disease within 5 years of …
remains an incurable disease where patients typically succumb to the disease within 5 years of …
[HTML][HTML] Complex Structural Variation Associated with Enhancer Hijacking and Loss of Tumor Suppressors in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a rare, incurable mature B-cell lymphoma that can have
either an aggressive or indolent clinical course. The hallmark aberration of MCL is the t(11;14)(…
either an aggressive or indolent clinical course. The hallmark aberration of MCL is the t(11;14)(…