User profiles for Prashant Emani
Prashant EmaniAssociate Research Scientist, Yale University Verified email at yale.edu Cited by 2299 |
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
[HTML][HTML] Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
Quantum computing at the frontiers of biological sciences
Computing plays a critical role in the biological sciences but faces increasing challenges of
scale and complexity. Quantum computing, a computational paradigm exploiting the unique …
scale and complexity. Quantum computing, a computational paradigm exploiting the unique …
[HTML][HTML] An integrative ENCODE resource for cancer genomics
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia
covers hundreds of cell types, providing a universal annotation for genome interpretation. …
covers hundreds of cell types, providing a universal annotation for genome interpretation. …
Insights from incorporating quantum computing into drug design workflows
Motivation While many quantum computing (QC) methods promise theoretical advantages
over classical counterparts, quantum hardware remains limited. Exploiting near-term QC in …
over classical counterparts, quantum hardware remains limited. Exploiting near-term QC in …
[PDF][PDF] Data sanitization to reduce private information leakage from functional genomics
The generation of functional genomics datasets is surging, because they provide insight into
gene regulation and organismal phenotypes (eg, genes upregulated in cancer). The intent …
gene regulation and organismal phenotypes (eg, genes upregulated in cancer). The intent …
Silica morphogenesis by lysine-leucine peptides with hydrophobic periodicity
AC Zane, C Michelet, A Roehrich, PS Emani… - Langmuir, 2014 - ACS Publications
The use of biomimetic approaches in the production of inorganic nanostructures is of great
interest to the scientific and industrial community due to the relatively moderate physical …
interest to the scientific and industrial community due to the relatively moderate physical …
Binding peptide generation for MHC Class I proteins with deep reinforcement learning
Motivation MHC Class I protein plays an important role in immunotherapy by presenting
immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC …
immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC …
A study of phenylalanine side-chain dynamics in surface-adsorbed peptides using solid-state deuterium NMR and rotamer library statistics
K Li, PS Emani, J Ash, M Groves… - Journal of the American …, 2014 - ACS Publications
Extracellular matrix proteins adsorbed onto mineral surfaces exist in a unique environment
where the structure and dynamics of the protein can be altered profoundly. To further …
where the structure and dynamics of the protein can be altered profoundly. To further …
A REDOR ssNMR investigation of the role of an N-Terminus Lysine in R5 Silica recognition
Diatoms are unicellular algae that construct cell walls called frustules by the precipitation of
silica, using special proteins that order the silica into a wide variety of nanostructures. The …
silica, using special proteins that order the silica into a wide variety of nanostructures. The …