As the concentrations of highly consumed nutrients, particularly glucose, are generally lower
in tumours than in normal tissues 1 , 2 , cancer cells must adapt their metabolism to the …

Apicomplexan parasites are leading causes of human and livestock diseases such as malaria
and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we present the …

Carcinoma cells residing in an intermediate phenotypic state along the epithelial–mesenchymal
(E–M) spectrum are associated with malignant phenotypes, such as invasiveness, tumor…

Mutations in numerous genes encoding ribosomal proteins (RPs) occur in 50%–70% of
individuals with Diamond-Blackfan anemia (DBA), establishing the disease as a ribosomopathy. …

The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key
to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome …

INTRODUCTION Tumor-initiating cells (TICs) have emerged in recent years as important
targets for cancer therapy owing to their elevated resistance to conventional chemotherapy and …

Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan
anemia (DBA) 1 , 2 , congenital asplenia 3 and T cell leukemia 4 . Yet, how …

Neoplastic cells within individual carcinomas often exhibit considerable phenotypic heterogeneity
in their epithelial versus mesenchymal-like cell states. Because carcinoma cells with …

Epithelial–mesenchymal transition (EMT) programs operate within carcinoma cells, where
they generate phenotypes associated with malignant progression. In their various …

Many human aneuploidy syndromes have unique phenotypic consequences, but in most
instances it is unclear whether these phenotypes are attributable to alterations in the dosage of …