User profiles for Premysl Jiruska
 | Premysl JiruskaSecond Faculty of Medicine, Charles University Verified email at lfmotol.cuni.cz Cited by 3145 |
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges
(IEDs) in seizure generation are two of the most important unresolved issues in modern …
(IEDs) in seizure generation are two of the most important unresolved issues in modern …
Synchronization and desynchronization in epilepsy: controversies and hypotheses
P Jiruska, M De Curtis, JGR Jefferys… - The Journal of …, 2013 - Wiley Online Library
Epilepsy has been historically seen as a functional brain disorder associated with excessive
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …
[HTML][HTML] Critical slowing down as a biomarker for seizure susceptibility
The human brain has the capacity to rapidly change state, and in epilepsy these state
changes can be catastrophic, resulting in loss of consciousness, injury and even death. …
changes can be catastrophic, resulting in loss of consciousness, injury and even death. …
High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro
P Jiruska, J Csicsvari, AD Powell, JE Fox… - Journal of …, 2010 - Soc Neuroscience
How seizures start is a major question in epilepsy research. Preictal EEG changes occur in
both human patients and animal models, but their underlying mechanisms and relationship …
both human patients and animal models, but their underlying mechanisms and relationship …
Chimera states in brain networks: Empirical neural vs. modular fractal connectivity
Complex spatiotemporal patterns, called chimera states, consist of coexisting coherent and
incoherent domains and can be observed in networks of coupled oscillators. The interplay of …
incoherent domains and can be observed in networks of coupled oscillators. The interplay of …
High‐frequency oscillations as a new biomarker in epilepsy
The discovery that electroencephalography (EEG) contains useful information at frequencies
above the traditional 80Hz limit has had a profound impact on our understanding of brain …
above the traditional 80Hz limit has had a profound impact on our understanding of brain …
Update on the mechanisms and roles of high‐frequency oscillations in seizures and epileptic disorders
High‐frequency oscillations ( HFO s) are a type of brain activity that is recorded from brain
regions capable of generating seizures. Because of the close association of HFO s with …
regions capable of generating seizures. Because of the close association of HFO s with …
Detection of interictal epileptiform discharges using signal envelope distribution modelling: application to epileptic and non-epileptic intracranial recordings
…, JGR Jefferys, P Krsek, V Komarek, P Jiruska… - Brain topography, 2015 - Springer
Interictal epileptiform discharges (spikes, IEDs) are electrographic markers of epileptic tissue
and their quantification is utilized in planning of surgical resection. Visual analysis of long-…
and their quantification is utilized in planning of surgical resection. Visual analysis of long-…
Resection of individually identified high‐rate high‐frequency oscillations region is associated with favorable outcome in neocortical epilepsy
Objectives High‐frequency oscillations ( HFO s) represent a novel electrophysiologic
marker of endogenous epileptogenicity. Clinically, this propensity can be utilized to more …
marker of endogenous epileptogenicity. Clinically, this propensity can be utilized to more …
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been
implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are …
implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are …