Background Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading
to dementia. The field has made significant progress over the last 15 years. AD diagnosis …

The neural tube consists of neural progenitors (NPs) that acquire different characteristics
during gestation due to patterning factors. However, the influence of such patterning factors on …

Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in the genes
EIF2B1-EIF2B5. It is characterized by chronic neurologic deterioration with superimposed …

Objective Astrocytes have gained attention as important players in neurological disease. In
line with their heterogeneous character, defects in specific astrocyte subtypes have been …

Leukodystrophies are often devastating diseases, presented with progressive clinical signs
as spasticity, ataxia and cognitive decline, and lack proper treatment options. New therapy …

Background The leukodystrophy “Vanishing White Matter” (VWM) is an orphan disease with
neurological decline and high mortality. Currently, VWM has no approved treatments, but …

Stem cell therapy has great prospects for brain white matter disorders, including the
genetically determined disorders called leukodystrophies. We focus on the devastating …

White matter disorders are characterized by deficient myelin or myelin loss, lead to a range
of neurologic dysfunctions, and can result in early death. Oligodendrocytes, which are …

Introduction Vanishing white matter (VWM) is a leukodystrophy that leads to neurological
dysfunction and early death. Astrocytes are indicated as therapeutic target, because of their …

Background: The leukodystrophy “Vanishing White Matter”(VWM) is an orphan disease with
neurological decline and high mortality. Currently, VWM has no approved treatments, but …