Highlights • Viral RNA genomes are modified by epitranscriptomic marks, such as 2′-O-methylation.
• 2′-O-methylations are self-markers hijacked by viruses to avoid immune sensing…

The guanosine analog AT-527 represents a promising candidate against Severe Acute
Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered phase III …

RNA 2′O-methylation is a ‘self’ epitranscriptomic modification allowing discrimination
between host and pathogen. Indeed, human immunodeficiency virus 1 (HIV-1) induces 2′O-…

Enteroviruses (family Picornaviridae) comprise a large group of human pathogens against
which no licensed antiviral therapy exists. Drug-repurposing screens uncovered the FDA-…

As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping
machinery to ensure the efficient translation of their messenger RNAs (mRNAs), protect them …

Enteroviruses are globally prevalent human pathogens responsible for many diseases. The
nonstructural protein 2C is a AAA+ helicase and plays a key role in enterovirus replication. …

How viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we
show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (…

Viral exoribonucleases are uncommon in the world of RNA viruses. To date, they have only
been identified in the Arenaviridae and the Coronaviridae families. The exoribonucleases of …

Snakebite envenoming can be a life-threatening medical emergency that requires prompt
medical intervention to neutralise the effects of venom toxins. Each year up to 138,000 people …

Schematic representation of the EV genome and 2C protein architecture.(A) Genomic and
protein organization of EVs. The EV genome is composed of two open reading frames (uORF …