Biofilms are dynamic microbial communities in which transitions between planktonic and
sessile modes of growth occur interchangeably in response to different environmental cues. In …

The incidence of fungal infections has increased significantly over the past decades. Very
often these infections are associated with biofilm formation on implanted biomaterials and/or …

Objectives We sought to develop a novel model of central venous catheter (CVC)-associated
candidiasis in mice and to use this model to examine the efficacy of caspofungin to treat …

Candida albicans biofilms on most medical devices are exposed to a flow of body fluids that
provide water and nutrients to the fungal cells. While C. albicans biofilms grown in vitro …

Background Hsp90 is an environmentally contingent molecular chaperone that influences
the form and function of diverse regulators of cellular signaling. Hsp90 potentiates the …

Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments
due to intrinsic drug resistance. These complex communities of multiple cell types form on …

… Reports by the Uppuluri group has demonstrated that the hyphae-to-yeast transition is
paramount for dispersal; dispersed cells are yeast cells released from the lateral septal regions of …

DNA has been described as a structural component of the extracellular matrix (ECM) in
bacterial biofilms. In Candida albicans, there is a scarce knowledge concerning the contribution …

Calcineurin is a Ca 2+ -calmodulin-activated serine/threonine-specific protein phosphatase
that governs multiple aspects of fungal physiology, including cation homeostasis, …

… Author links open overlay panel Christopher G Pierce 1 3 , Anand Srinivasan 2 3 , Priya
Uppuluri 1 3 , Anand K Ramasubramanian 2 3 , José L López-Ribot 1 … Uppuluri, JL Lopez-Ribot …