Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials
for investigating cell–substrate interactions in vitro. Foam morphologies can be controlled …

Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular
basis for this heterogeneity, we performed genome-wide pooled RNA interference screens …

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to
change the efficiency, effectiveness, and costs of the drug discovery process; to advance …

B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that
regulates cell growth and differentiation in multiple tissues, including skin. Although in the …

It is well established that topographical features modulate cell behaviour, including cell
morphology, proliferation and differentiation. To define the effects of topography on human …

We describe the preparation of porous polymeric scaffolds via polymerization of the oil
phase in high internal phase water-in-oil-emulsions using amphiphilic block copolymers …

In human skin the interface between the epidermis and dermis is not flat, but undulates. The
dimensions of the undulations change as a function of age and disease. Epidermal stem cell …

The design of novel biomaterials for regenerative medicine requires incorporation of well-defined
physical and chemical properties that mimic the native extracellular matrix (ECM). Here…

Surface patterning in three dimensions is of great importance in biomaterials design for
controlling cell behavior. A facile one-step functionalization of biodegradable PDLLA fibers using …

10.7554/eLife.27356.001 Epidermal homeostasis depends on a balance between stem cell
renewal and terminal differentiation. The transition between the two cell states, termed …