User profiles for Priyamvada Acharya
 | Priyamvada AcharyaDuke University Verified email at mail.nih.gov Cited by 8667 |
[HTML][HTML] Controlling the SARS-CoV-2 spike glycoprotein conformation
…, AL Hsu, MJ Borgnia, BF Haynes, P Acharya - Nature structural & …, 2020 - nature.com
The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary
immunogenic target for virus neutralization and the current focus of many vaccine design efforts. …
immunogenic target for virus neutralization and the current focus of many vaccine design efforts. …
[PDF][PDF] In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
…, DC Montefiori, GD Sempowski, RS Baric, P Acharya… - Cell, 2021 - cell.com
SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding
SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated …
SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated …
[PDF][PDF] D614G spike mutation increases SARS CoV-2 susceptibility to neutralization
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired
a D614G mutation early in the pandemic that confers greater infectivity and is now the …
a D614G mutation early in the pandemic that confers greater infectivity and is now the …
[PDF][PDF] D614G mutation alters SARS-CoV-2 spike conformation and enhances protease cleavage at the S1/S2 junction
…, R Henderson, RJ Edwards, BF Haynes, P Acharya - Cell reports, 2021 - cell.com
The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a …
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a …
[PDF][PDF] Pandemic preparedness: developing vaccines and therapeutic antibodies for COVID-19
GD Sempowski, KO Saunders, P Acharya, KJ Wiehe… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused
global public health and economic crises, necessitating rapid development of vaccines and …
global public health and economic crises, necessitating rapid development of vaccines and …
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have been circulating worldwide since the beginning of the pandemic. Some are termed …
have been circulating worldwide since the beginning of the pandemic. Some are termed …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
[HTML][HTML] Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and
Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (…
Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (…
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
As the sole viral antigen on the HIV-1–virion surface, trimeric Env is a focus of vaccine efforts.
Here we present the structure of the ligand-free HIV-1–Env trimer, fix its conformation and …
Here we present the structure of the ligand-free HIV-1–Env trimer, fix its conformation and …