The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the
past decade. However, non-coding cancer driver mutations are less well-characterized and …

Recent studies have shown that mutations at non-coding elements, such as promoters and
enhancers, can act as cancer drivers. However, an important class of non-coding elements, …

Background The advent of human genome sequencing project has led to a spurt in the
number of protein sequences in the databanks. Success of structure based drug discovery …

Discovery of cancer drivers has traditionally focused on the identification of protein-coding
genes. Here we present a comprehensive analysis of putative cancer driver mutations in both …

Introduction PL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R).
PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat …

Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease. To
discover germline events involved in prostate cancer predisposition, we develop a …

We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using
the combined effects of coding and non-coding single nucleotide variants, structural variants…

Protein folding, considered to be the holy grail of molecular biology, remains intractable even
after six decades since the report of the first crystal structure. Over 70,000 X-ray and NMR …

Purpose: Unboxing is a relatively new social media occurrence, where a YouTube unboxer’s
amateur video gradually unwraps and reviews a new product for the followers. The …