Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
TJ Hoffmann, GB Ehret, P Nandakumar, D Ranatunga… - Nature …, 2017 - nature.com
Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …
Genetic analyses identify widespread sex-differential participation bias
N Pirastu, M Cordioli, P Nandakumar, G Mignogna… - Nature Genetics, 2021 - nature.com
Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …
does not affect downstream analyses. Understanding the genetic basis of participation bias …
Nuclear genome-wide associations with mitochondrial heteroplasmy
P Nandakumar, C Tian, J O'Connell… - Science …, 2021 - science.org
The role of the nuclear genome in maintaining the stability of the mitochondrial genome (mtDNA)
is incompletely known. mtDNA sequence variants can exist in a state of heteroplasmy, …
is incompletely known. mtDNA sequence variants can exist in a state of heteroplasmy, …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
…, AD Morris, AC Morrison, PJ Munson, P Nandakumar… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
…, AC Morrison, PJ Munson, P Nandakumar… - …, 2017 - Am Heart Assoc
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …
genetic contribution. Genetic variation influencing blood pressure has the potential to …
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into …
Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily
attributable to its symptom-based definitions. GERD genome-wide association studies (…
attributable to its symptom-based definitions. GERD genome-wide association studies (…
[PDF][PDF] Genome-wide study identifies association between HLA-B∗ 55: 01 and self-reported penicillin allergy
…, JL Mountain, SV Mozaffari, P Nandakumar… - The American Journal of …, 2020 - cell.com
Hypersensitivity reactions to drugs are often unpredictable and can be life threatening,
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …
[HTML][HTML] MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension
Background In older adults (aged 70–74 years), African-Americans have 4-fold higher risk
of developing hypertension-attributed end-stage renal disease (ESRD) than European-…
of developing hypertension-attributed end-stage renal disease (ESRD) than European-…
Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease
…, I Matera, SS Cherny, P Nandakumar… - Human molecular …, 2016 - academic.oup.com
Hirschsprung disease (HSCR) is the most common cause of neonatal intestinal obstruction.
It is characterized by the absence of ganglia in the nerve plexuses of the lower …
It is characterized by the absence of ganglia in the nerve plexuses of the lower …