Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …

Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …

Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …

The role of the nuclear genome in maintaining the stability of the mitochondrial genome (mtDNA)
is incompletely known. mtDNA sequence variants can exist in a state of heteroplasmy, …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …

Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily
attributable to its symptom-based definitions. GERD genome-wide association studies (…

Hypersensitivity reactions to drugs are often unpredictable and can be life threatening,
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …

Background In older adults (aged 70–74 years), African-Americans have 4-fold higher risk
of developing hypertension-attributed end-stage renal disease (ESRD) than European-…

Hirschsprung disease (HSCR) is the most common cause of neonatal intestinal obstruction.
It is characterized by the absence of ganglia in the nerve plexuses of the lower …