Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

The epithelial Na + channel (ENaC) is essential for Na + homeostasis, and dysregulation of
this channel underlies many forms of hypertension. Recent studies suggest that mTOR …

The ubiquitously expressed adapter proteins Nck1/2 interact with a multitude of effector
molecules to regulate diverse cellular functions including cytoskeletal dynamics. Here we show …

Molecular assessments at the single cell level can accelerate biological research by providing
detailed assessments of cellular organization and tissue heterogeneity in both disease …

Maintenance of systemic homeostasis by kidney requires the coordinated response of diverse
cell types. The use of single-cell RNA sequencing (scRNAseq) for patient tissue samples …

Advancement in proteomics methods for interrogating biological samples has helped identify
disease biomarkers for early diagnostics and unravel underlying molecular mechanisms of …

Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that
controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been …

Tropomyosins are widespread actin‐binding proteins that influence numerous cellular
functions including actin dynamics, cell migration, tumour suppression, and Drosophila oocyte …

COVID-19 has posed a significant threat to global health. Early data has revealed that IL-6, a
key regulatory cytokine, plays an important role in the cytokine storm of COVID-19. Multiple …

Background The kidney is a highly complex organ that performs multiple functions necessary
to maintain systemic homeostasis, with complex interplay from different kidney sub-…