User profiles for Priyesh Mohanty
 | Priyesh MohantyPostdoctoral Researcher, Artie McFerrin Dept. of Chemical Engineering, Texas A&M … Verified email at tamu.edu Cited by 107 |
Principles governing the phase separation of multidomain proteins
A variety of membraneless organelles, often termed “biological condensates”, play an important
role in the regulation of cellular processes such as gene transcription, translation, and …
role in the regulation of cellular processes such as gene transcription, translation, and …
A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain
TAR DNA-binding protein 43 (TDP-43) is involved in key processes in RNA metabolism and
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
[HTML][HTML] NEDD8 Deamidation inhibits Cullin RING ligase dynamics
Cullin-RING ligases (CRLs) are a significant subset of Ubiquitin E3 ligases that regulate
multiple cellular substrates involved in innate immunity, cytoskeleton modeling, and cell cycle. …
multiple cellular substrates involved in innate immunity, cytoskeleton modeling, and cell cycle. …
Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases
The deamidase OspI from enteric bacteria Shigella flexneri deamidates a glutamine residue
in the host ubiquitin-conjugating enzyme UBC13 and converts it to glutamate (Q100E). …
in the host ubiquitin-conjugating enzyme UBC13 and converts it to glutamate (Q100E). …
Challenges in studying the liquid-to-solid phase transitions of proteins using computer simulations
“Membraneless organelles,” also referred to as biomolecular condensates, perform a variety
of cellular functions and their dysregulation is implicated in cancer and neurodegeneration. …
of cellular functions and their dysregulation is implicated in cancer and neurodegeneration. …
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation
The misfolding and mutation of Cu/Zn superoxide dismutase (SOD1) is commonly associated
with amyotrophic lateral sclerosis (ALS). SOD1 can accumulate within stress granules (SGs…
with amyotrophic lateral sclerosis (ALS). SOD1 can accumulate within stress granules (SGs…
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP‐43 and modulates its phase behavior
TAR DNA‐binding protein 43 (TDP‐43) is a multidomain protein involved in the regulation
of RNA metabolism, and its aggregates have been observed in neurodegenerative diseases, …
of RNA metabolism, and its aggregates have been observed in neurodegenerative diseases, …
[PDF][PDF] Multiscale simulations reveal TDP-43 molecular-level interactions driving condensation
The RNA-binding protein TDP-43 is associated with mRNA processing and transport from
the nucleus to the cytoplasm. TDP-43 localizes in the nucleus as well as accumulating in …
the nucleus to the cytoplasm. TDP-43 localizes in the nucleus as well as accumulating in …
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
Cytosolic aggregation of the nuclear protein TDP-43 is associated with many
neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we …
neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we …
[HTML][HTML] Specific residues and conformational plasticity define the substrate specificity of short-chain dehydrogenases/reductases
Short-chain dehydrogenases/reductases (SDRs) are one of the most prevalent enzyme families
distributed among the sequenced microorganisms. Despite the presence of a conserved …
distributed among the sequenced microorganisms. Despite the presence of a conserved …