NMDA receptor dysfunction contributes to impaired brain‐derived neurotrophic factor‐induced facilitation of hippocampal synaptic transmission in a T au transgenic …
…, M Hamdane, S Humez, P Popoli, L Buee… - Aging cell, 2013 - Wiley Online Library
While the spatiotemporal development of Tau pathology has been correlated with occurrence
of cognitive deficits in A lzheimer's patients, mechanisms underlying these deficits remain …
of cognitive deficits in A lzheimer's patients, mechanisms underlying these deficits remain …
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease
NMR spectroscopy was used to explore the different aspects of the normal and pathological
functions of tau, but proved challenging because the protein contains 441 amino acids and …
functions of tau, but proved challenging because the protein contains 441 amino acids and …
[HTML][HTML] 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides
…, H Drobecq, P Rousselot-Pailley, L Buée… - Journal of Biological …, 2001 - ASBMB
The recent crystal structure of Pin1 protein bound to a doubly phosphorylated peptide from
the C-terminal domain of RNA polymerase II revealed that binding interactions between Pin1 …
the C-terminal domain of RNA polymerase II revealed that binding interactions between Pin1 …
Dementia beyond 2025: Knowledge and uncertainties
Given that there may well be no significant advances in drug development before 2025,
prevention of dementia–Alzheimer’s disease through the management of vascular and lifestyle-…
prevention of dementia–Alzheimer’s disease through the management of vascular and lifestyle-…
[HTML][HTML] Transforming growth factor-β1 potentiates amyloid-β generation in astrocytes and in transgenic mice
Accumulation of the amyloid-β peptide (Aβ) in the brain is crucial for development of Alzheimer's
disease. Expression of transforming growth factor-β1 (TGF-β1), an immunosuppressive …
disease. Expression of transforming growth factor-β1 (TGF-β1), an immunosuppressive …
GnRH replacement rescues cognition in Down syndrome
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive nonreproductive …
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive nonreproductive …
[HTML][HTML] Nuclear tau, a key player in neuronal DNA protection
Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease,
which is primarily described as a microtubule-associated protein, has also been observed …
which is primarily described as a microtubule-associated protein, has also been observed …
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment
…, N Zommer, N Sergeant, V Buée-Scherrer… - The Journal of the …, 2012 - pubs.asahq.org
Background There is a growing interest in the involvement of anesthetic agents in the
etiology of postoperative cognitive dysfunction. Recent animal studies suggest that acute …
etiology of postoperative cognitive dysfunction. Recent animal studies suggest that acute …
[HTML][HTML] Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
…, A Delacourte, JC Beauvillain, L Buee… - Journal of Biological …, 2007 - ASBMB
Amyloid precursor protein (APP) metabolism is central to the pathogenesis of Alzheimer
disease. We showed recently that the amyloid intracellular domain (AICD), which is released by …
disease. We showed recently that the amyloid intracellular domain (AICD), which is released by …
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
… We thank in particular Prof. Mathias Jucker for making the line APP/PS1 available for our
research and for providing us with an … Luc Buée is supported by grant ANR-16-COEN-0007. …
research and for providing us with an … Luc Buée is supported by grant ANR-16-COEN-0007. …