We demonstrate that the Parkinson’s VPS35[D620N] mutation alters the expression of ~220
lysosomal proteins and stimulates recruitment and phosphorylation of Rab proteins at the …

Rab8a is associated with the dynamic regulation of membrane protrusions in polarized cells.
Rab8a is one of several Rab GTPases that are substrates of leucine-rich repeat kinase 2 (…

Autosomal dominant mutations in LRRK2 that enhance kinase activity cause Parkinson's
disease. LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10 within …

Wilson disease (WD) is an autosomal‐recessive disorder caused by mutations in the ATP7B
gene leading to abnormal copper deposition in liver and brain. WD manifests diverse …

Parkinson’s disease (PD) is a progressive neurodegenerative disease with complex etiology.
Both genetic and environmental factors play significant role. Apart from candidate genes, …

Wilson’s disease (WD), an inborn error of copper metabolism caused by mutations in the
ATPase copper transporting beta (ATP7B) gene, manifests variable age of onset and different …

Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a complex etiology.
Presence of autosomal mutations in PARK7/DJ-1 gene has been associated with early-…

India-Pakistan relations have been mired in conflict since their inception ass independent
states-it remains virtually, as aptly quoted my Michael Brecher, as a constant state of an …

The neighborhood policy of a country is usually regarded as a subset of its foreign policy.
This is no exception in the case of India. There has been a critical response to India’s …

The region of South Asia has been one of the most strategically relevant, and at the same
time, vulnerable, in the realms of International Politics. The most profound factor which has …