The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of
current mtDNA sequencing methods. We developed individual Mitochondrial Genome …

Maternal mitochondria are the sole source of mtDNA for every cell of the offspring. Heteroplasmic
mtDNA mutations inherited from the oocyte are a common cause of metabolic diseases …

In addition to the great growing need for assisted reproduction technologies (ART), additional
solutions for patients without functional gametes are strongly needed. Due to ethical …

Since the conception of precision medicine has been put forward in oncology, this idea has
been popularized and applied in many specialties. Significant progress has been made …

Oxybenzone (OBZ), an ultraviolet light filter that is widely used in sunscreens and cosmetics,
is an emerging contaminant found in humans and the environment. Recent studies have …

Human zygotes are difficult to obtain for research because of limited resources and ethical
debates. Corrected human tripronuclear (ch3PN) zygotes obtained by removal of the extra …

The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of
current mtDNA sequencing methods. We developed individual Mitochondrial Genome …

Uropathogenic Escherichia coli (UPEC) is the most prevalent causative agent of urinary tract
infections (UTIs). The pathogenicity of UPEC relies on the expression of virulence factors …

The Brassica genus encompasses three diploid and three allopolyploid genomes, but a clear
understanding of the evolution of agriculturally important traits via polyploidy is lacking. We …

N 6 -Methyladenine (6mA) DNA methylation has recently been implicated as a potential new
epigenetic marker in eukaryotes, including the dicot model Arabidopsis thaliana. However, …