Recent advances in nanoparticle technology have enabled the fabrication of nanoparticle
classes with unique sizes, shapes and materials, which in turn has facilitated major …

While nanoparticles maximize the amount of chemotherapeutic drug in tumors relative to
normal tissues, nanoparticle-based drugs are not accessible to the majority of cancer cells …

While the enhanced permeability and retention effect may promote the preferential accumulation
of nanoparticles into well-vascularized primary tumors, it is ineffective in the case of …

Various targeting strategies and ligands have been employed to direct nanoparticles to
tumors that upregulate specific cell-surface molecules. However, tumors display a dynamic, …

The design of nanoscale yet highly echogenic agents for imaging outside of the vasculature
and for ultrasound-mediated drug delivery remains a formidable challenge. We have …

Glioblastoma multiforme is generally recalcitrant to current surgical and local radiotherapeutic
approaches. Moreover, systemic chemotherapeutic approaches are impeded by the blood…

Purpose Pluronic has been shown to sensitize various tumor cell lines to chemotherapy and
hyperthermia by altering the membrane fluidity, depleting ATP, and modulating the heat …

Contrast-enhanced ultrasound with microbubbles has shown promise in detection of
prostate cancer (PCa), but sensitivity and specificity remain challenging. Targeted nanoscale-…

Tumors present numerous biobarriers to the successful delivery of nanoparticles. Decreased
blood flow and high interstitial pressure in tumors dictate the degree of resistance to …

Metastasis displays a highly heterogeneous cellular population with cancer cells continuously
evolving. As a result, a single-ligand nanoparticle cannot account for the continuously …