Migraine with aura is a common but poorly understood sensory circuit disorder. Monogenic
models allow an opportunity to investigate its mechanisms, including spreading …

Edema is an important target for clinical intervention after traumatic brain injury (TBI). We used
in vivo cellular resolution imaging and electrophysiological recording to examine the ionic …

Acute Neuroinflammation Leads to Disruption of Neuronal Chloride Regulation and Consequent
Hyperexcitability in the Dentate Gyrus Kurki SN, Srinivasan R, Laine J, Virtanen MA, Ala…

Migraine is a very common and disabling neurological disorder that remains poorly understood
at 7 the cellular and circuit level. Transgenic mice harboring a mutation in casein kinase …

Migraine is a common and disabling neurological disorder. The headache and sensory
amplifications of migraine are attributed to hyperexcitable sensory circuits, but a detailed …

We used in vivo whole-cell techniques to record the membrane potential from layer 2/3 neurons
in mouse somatosensory cortex during CSD (n= 8-10 mice). Spontaneous postsynaptic …

Migraine is a pervasive neurological disorder involving craniofacial pain and disruptions in
sensory perception, though an incomplete understanding of the mechanisms of migraine …

Migraine is a prevalent (12% of the world population) and severely debilitating disorder with
complex pathophysiology, which imposes a significant economic burden on society. Clinical …

… were obtained from regular spiking pyramidal neurons (Sawant-Pokam et al., 2017) in L2/3 …
We thank Patrick Parker and Punam Sawant-Pokam for providing technical direction. …

… (SawantPokam et al., 2017). We used in vivo whole-cell techniques to record the membrane
potential from S1 L2/3 pyramidal neurons and analyzed spontaneous up states in current-…