User profiles for Purushothama Rao Tata

Purushothama Rao Tata

Duke University (Previously at MGH and Harvard University)
Verified email at duke.edu
Cited by 13736

[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

…, D Pe'er, J Powell, S Quake, J Rajagopal, PR Tata… - Cell, 2020 - cell.com
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

Dedifferentiation of committed epithelial cells into stem cells in vivo

PR Tata, H Mou, A Pardo-Saganta, R Zhao, M Prabhu… - Nature, 2013 - nature.com
Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost
fishes and amphibians. In vertebrates, differentiated cells are known to revert into replicating …

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

…, L Nguyen, D Dionne, O Rozenblatt-Rosen, PR Tata… - Nature, 2018 - nature.com
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-…

[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction

H Katsura, V Sontake, A Tata, Y Kobayashi… - Cell stem cell, 2020 - cell.com
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

Y Kobayashi, A Tata, A Konkimalla, H Katsura… - Nature cell …, 2020 - nature.com
Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However,
the identity of transitional states and the mechanisms that drive their trajectories remain …

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

P Kadur Lakshminarasimha Murthy, V Sontake, A Tata… - Nature, 2022 - nature.com
Mapping the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of human …

Plasticity in the lung: making and breaking cell identity

PR Tata, J Rajagopal - Development, 2017 - journals.biologists.com
In contrast to a prior emphasis on the finality of cell fate decisions in developmental systems,
cellular plasticity is now emerging as a general theme in the biology of multiple adult organ …

[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

…, H Hibshoosh, W Hide, AL Price, J Rajagopal, PR Tata… - Nature, 2021 - nature.com
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …

[PDF][PDF] Dual SMAD signaling inhibition enables long-term expansion of diverse epithelial basal cells

H Mou, V Vinarsky, PR Tata, K Brazauskas, SH Choi… - Cell stem cell, 2016 - cell.com
Functional modeling of many adult epithelia is limited by the difficulty in maintaining relevant
stem cell populations in culture. Here, we show that dual inhibition of SMAD signaling …

[HTML][HTML] An integrated cell atlas of the lung in health and disease

…, KB Meyer, JA Kropski, D Pe'er, HB Schiller, PR Tata… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …