Microbiota-derived metabolites as drivers of gut–brain communication
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
[HTML][HTML] Neuroinflammation in autism: plausible role of maternal inflammation, dietary omega 3, and microbiota
C Madore, Q Leyrolle, C Lacabanne… - Neural …, 2016 - hindawi.com
… Charlotte Madore and Quentin Leyrolle equally contributed to … Quentin Leyrolle, Corinne
Joffre, Chloé Lacabanne, Agnes Nadjar, … Quentin Leyrolle is funded by the Institut National de la …
Joffre, Chloé Lacabanne, Agnes Nadjar, … Quentin Leyrolle is funded by the Institut National de la …
[HTML][HTML] Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial …
…, I Diaz-Aparicio, A Nadjar, S Layé, Q Leyrolle… - PLoS …, 2016 - journals.plos.org
Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory
and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent …
and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent …
Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
…, AM Neyrinck, T Le Roy, SA Pötgens, Q Leyrolle… - Gut, 2020 - gut.bmj.com
… The p-value of the Welch’s t-test was adjusted (q-value, significant if q<0.05) to control for
the false discovery rate (FDR) for multiple tests according to the Benjamini and Hochberg …
the false discovery rate (FDR) for multiple tests according to the Benjamini and Hochberg …
[HTML][HTML] Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
C Madore, Q Leyrolle, L Morel, M Rossitto… - Nature …, 2020 - nature.com
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain.
Westernization of dietary habits in both developed and developing countries is accompanied by …
Westernization of dietary habits in both developed and developing countries is accompanied by …
[PDF][PDF] Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder
… q < 0.05 versus CT-recipient mice (FDR correction), unpaired t tests with Welch’s correction.
(I) … Significant correlations are marked with a star, *q < 0.05; **q < 0.001 (FDR correction). …
(I) … Significant correlations are marked with a star, *q < 0.05; **q < 0.001 (FDR correction). …
[HTML][HTML] Link between gut microbiota and health outcomes in inulin-treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled …
…, J Rodriguez, D Portheault, Q Leyrolle… - Clinical Nutrition, 2020 - Elsevier
Background The gut microbiota is altered in obesity and is strongly influenced by nutrients
and xenobiotics. We have tested the impact of native inulin as prebiotic present in vegetables …
and xenobiotics. We have tested the impact of native inulin as prebiotic present in vegetables …
Direct and indirect effects of lipids on microglia function
Q Leyrolle, S Laye, A Nadjar - Neuroscience Letters, 2019 - Elsevier
Microglia are key players in brain function by maintaining brain homeostasis across lifetime.
They participate to brain development and maturation through their ability to release …
They participate to brain development and maturation through their ability to release …
Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation
VF Labrousse, Q Leyrolle, C Amadieu, A Aubert… - Brain, behavior, and …, 2018 - Elsevier
Maternal immune activation (MIA) is a common environmental insult on the developing brain
and represents a risk factor for neurodevelopmental disorders. Animal models of in utero …
and represents a risk factor for neurodevelopmental disorders. Animal models of in utero …
[HTML][HTML] Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial
Q Leyrolle, R Cserjesi, MDGH Mulders… - Brain, behavior, and …, 2021 - Elsevier
Background and aims Metabolic and behavioural diseases, which are often related to obesity,
have been associated to alterations of the gut microbiota considered as an interesting …
have been associated to alterations of the gut microbiota considered as an interesting …