The migration of neuronal precursors along radial glial fibers is a critical step in the formation
of the nervous system. In this report, we show that neuregulin–erbB receptor signaling …

Wound healing capability is inextricably linked with diverse aspects of physical fitness
ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. …

The development of mature B cells involves a series of molecular decisions which culminate
in the expression of a single light-chain and heavy-chain antigen receptor on the cell …

The decline of circulating testosterone levels in aging men is associated with adverse health
effects. During studies of probiotic bacteria and obesity, we discovered that male mice …

Searching for factors to improve knockin efficiency for therapeutic applications, biotechnology,
and generation of non-human primate models of disease, we found that the strand …

Random monoallelic expression and asynchronous replication define an unusual class of
autosomal mammalian genes. We show that every cell has randomly chosen either the …

Genome editing has transformed biomedical science, but is still unpredictable and often
induces undesired outcomes. Prime editing (PE) is a promising new approach due to its …

The number of autosomal mammalian genes subject to random monoallelic expression has
been limited to genes highly specific to the function of chemosensory neurons or …

THE RETROVIRUS-MEDIATED TRANSFER of the herpes simplex virus-thymidine kinase (HSV-tk)
gene into tumor cells renders them sensitive to the cytocidal effect of the antiviral …

✓ A promising strategy in the treatment of neoplastic meningitis involves the use of herpes
simplex virus—thymidine kinase (HSV-tk)—modified cells. In these experiments the authors …