Direct lineage reprogramming is a promising approach for human disease modeling and
regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical …

Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states 1 , 2 , 3 . However, the intermediate stages through which individual cells …

Direct conversion of nonneural cells to functional neurons holds great promise for
neurological disease modeling and regenerative medicine. We previously reported rapid …

How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here,
we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout …

Background Recent literature has revealed that genetic exchange of microRNA between
cells can be essential for cell-cell communication, tissue-specificity and developmental …

Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood–brain barrier
and placenta, and have the potential to elicit developmental neurotoxicity (DNT). Here, we …

Background & Aim Under the regulation of various oncogenic pathways, cancer cells undergo
adaptive metabolic programming to maintain specific metabolic states that support their …

10.7554/eLife.40197.001 Direct reprogramming of fibroblasts to neurons induces widespread
cellular and transcriptional reconfiguration. Here, we characterized global epigenomic …

10.7554/eLife.41770.001 Long noncoding RNAs (lncRNAs) have been shown to act as
important cell biological regulators including cell fate decisions but are often ignored in human …

The on-target pioneer factors Ascl1 and Myod1 are sequence-related but induce two
developmentally unrelated lineages—that is, neuronal and muscle identities, respectively. It is …